Rho GTPases in embryonic development

Rho-GTPases in Embryonic Stem Cells

Regulators of Rho GTPases in neuronal development.

The formation and elaboration of axonal and dendritic morphologies are fundamental aspects of neuronal polarization critical for information processing. In general, developing CNS neurons elaborate one axon and multiple dendrites in response to intracellular and extracellular cues, so as to transmit and receive information, respectively. The molecular mechanisms underlying axon-dendrite polarit...

Rho GTPases in endoderm development and differentiation

The embryonic foregut of the mouse embryo is lined by a layer of endoderm cells whose architecture changes during development. The transition from a squamous to columnar epithelial morphology is accompanied by the upregulation of an atypical Rho GTPase, Rhou. Subsequently, multi-layering of the epithelium at the site of organ bud formation is associated with the downregulation of Rhou. Rho-rela...

Rho GTPases

Cell migration is a complex, dynamic process that involves continuous remodeling of the cellular architecture, which is needed in order for the cell to move and adapt to changes in the surrounding environment. It requires rapidly activated and spatiotemporally regulated signaling networks that enable cellular responses to external cues. Rho-family GTPases are key components of these signaling n...

Rho Gtpases

The composition of the extracellular matrix (ECM) surrounding cells is key to their behavior: it modulates their ability to proliferate, differentiate, and migrate (Giancotti and Ruoslahti, 1999). ECM components can signal directly to cells through transmembrane receptors such as inte-grins, and can also present soluble cytokines and growth factors to cells. The morphology of cells varies great...